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KMID : 0363220080460040533
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Korean Journal of Dermatology
2008 Volume.46 No. 4 p.533 ~ p.537
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A Case of Metastatic Neuroendocrine Carcinoma of the Lung Concomitant with Adenocarcinoma of the Stomach
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Lee Hye-Young
Na So-Young
Baek Jin-Ok
Roh Ju-Young
Lee Jong-Rok
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Abstract
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Neuroendocrine tumors derive from the diffuse neuroendocrine system producing hormonal peptides and/or biogenic
amines. Histologically neuroendocrine differentiation includes ultrastructural demonstration of neurosecretory granules
and staining with immunhistochemical markers such as neuron-specific enolase, chromogranin, synaptophysin, and
cytokeratin. Neuroendocrine carcinoma of the skin is rare but can be shown as an initial manifestation of metastatic
neuroendocrine carcinoma as well as primary cutaneous neuroendocrine carcinoma. Histological differentiation
between primary cutaneous Merkel cell carcinoma and metastatic neuroendocrine carcinoma of the skin is difficult
and clinical correlation is important. We report a case of metastatic neuroendocrine carcinoma of the lung occurring
on the scalp as a single nodule in a 65-year-old female who previously diagnosed with adenocarcinoma of the
stomach. (Korean J Dermatol 2008;46(4):533∼537)
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KEYWORD
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Adenocarcinoma of the stomach, Metastatic neuroendocrine carcinoma of the Lung
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